Most patients with a benzodiazepine overdose will respond to a cumulative dose of 1 to 3 mg.Patients should have secure airway and venous access before administration, and be awakened gradually.Resedation: Repeated doses may be given at 20 minute intervals as needed Further doses of 0.5 mg over 30 seconds may be given at 1 minute intervals, if needed.If desired level of consciousness is not achieved after waiting 30 seconds, a second dose of 0.3 mg may be given over another 30 seconds.Usual Adult Dose for Benzodiazepine Overdose Use(s): Complete or partial reversal of the sedative effects of benzodiazepines where general anesthesia has been induced and/or maintained with benzodiazepines, or where sedation has been produced with benzodiazepines for diagnostic and therapeutic procedures. Administer as a series of small injections as described to control reversal of sedation to desired endpoint and minimize adverse effects.
Most patients respond to doses of 0.6 to 1 mg.Individualize dose based on patient response.Maximum dose: 1 mg total at any one time no more than 3 mg in any one hour Resedation: 0.2 mg every 20 minutes as needed Repeated doses: 0.2 mg may be given every minute until the desired level of consciousness is achieved. Initial dose: 0.2 mg IV one time over 15 seconds. Usual Adult Dose for Reversal of Sedation
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